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Current management

The KDIGO 2025 guidelines outline the updated management recommendations and targets for patients with IgA nephropathy (IgAN)1

KDIGO defines patients at risk of progressive loss of kidney function as those with proteinuria ≥0.5 g/day while on or off treatment with IgAN1

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The treatment goal in IgAN patients at risk of progressive loss of kidney function is to reduce the rate of loss of kidney function to the physiological state (<1 mL/min/year) for the rest of the patient’s life1

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Urine protein excretion (UPE) is the only validated early biomarker to help guide clinical decision making, and should be maintained at <0.5 g/day or ideally <0.3 g/day1*

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For most IgAN patients, management should focus simultaneously on:1

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Preventing or reducing IgA immune complex (IgA-IC) formation and immune complex-mediated glomerular injury

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Managing the consequences of existing
IgAN-induced nephron loss

Key Management Recommendation Changes from 2021 to 2025

UNDERSTANDING KDIGO: EXPERT INSIGHTS FROM PROFESSOR BARRATT

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Treatment targets in IgAN and the positioning of drugs included in this guideline

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Adapted from KDIGO 20251

CLICK HERE TO DISCOVER THE CURRENT TREATMENTS IN THE GUIDELINE

TWO PATHWAYS CONTRIBUTE TO DISEASE PROGRESSION IN IgAN

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